MODIFIED FACTOR X POLYPEPTIDES AND USES THEREOF

摘要

Modified therapeutic proteins are provided. In particular modified Factor X polypeptides, which includes the Factor X zymogen, Factor Xa and other forms of Factor X, and uses thereof are provided.

主权项

1. An isolated modified active Factor X (FXa) polypeptide, comprising an amino acid replacement at a position corresponding to position 196 in an unmodified FXa polypeptide based on mature numbering with reference to amino acid positions set forth in SEQ ID NO:134, wherein:
the replacement is with a neutral polar amino acid residue; and corresponding residues are identified by alignment with the polypeptide whose sequence is set forth in SEQ ID NO:134.