发明名称 |
DESIGNED ARMADILLO REPEAT PROTEINS |
摘要 |
The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections. |
申请公布号 |
CA2700391(A1) |
申请公布日期 |
2009.04.02 |
申请号 |
CA20082700391 |
申请日期 |
2008.09.23 |
申请人 |
UNIVERSITY OF ZUERICH |
发明人 |
PARMEGGIANI, FABIO;PELLARIN, RICCARDO;LARSEN, ANDERS PETER;VARADAMSETTY, GAUTHAM;STUMPP, MICHAEL TOBIAS;PLUECKTHUN, ANDREAS |
分类号 |
C12N15/10;A61K38/17;C07K14/47 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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