| 发明名称 |
SMALL MOLECULE INHIBITORS OF MCL-1 AND THE USES OF THEREOF |
| 摘要 |
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having sulfonamido-1-hydroxynaphthalene structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases. |
| 申请公布号 |
US2014235702(A1) |
申请公布日期 |
2014.08.21 |
| 申请号 |
US201214346584 |
申请日期 |
2012.10.08 |
| 申请人 |
WAYNE STATE UNIVERSITY ;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
Nikolovska-Coleska Zaneta;Showalter Hollis D.;Liao Chenzhong;Mohammad Ramzi;Abulwerdi Fardokht |
| 分类号 |
C07D333/62;A61K31/381;A61K45/06;A61K31/196;A61K31/165;C07D333/34;C07C321/28 |
主分类号 |
C07D333/62 |
| 代理机构 |
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代理人 |
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| 主权项 |
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| 地址 |
Detroit MI US |
