TREATMENT OF PHARMACOLOGICAL-INDUCED HYPOCHLORHYDRIA
摘要
Changes in gastric pH due to oral co-administration of acid-reducing agents, such as proton pump inhibitors, and oncology drugs can have a marked impact on the absorption and oral bioavailability of the oncology drug if the pH decreases the maximal absorbable dose. Moreover, there is a potential for specific drug-drug interactions between some of the acid-reducing agents and these drugs. Methods are described for treating patients on gastric acid-reducing therapy with orally-administered PI3K inhibitor compound GDC-0941. Treatment with a re-acidification compound during treatment with GDC-0941 improves bioavailability of GDC-0941.
申请公布号
EP2766011(A1)
申请公布日期
2014.08.20
申请号
EP20120780610
申请日期
2012.10.12
申请人
GENENTECH, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人
BENET, LESLIE Z.;DALZIEL, GENA;DEAN, BRIAN;DRESSER, MARK;FRYMOYER, ADAM;HOLDEN, SCOTT;JIN, JIN;WARE, JOSEPH A.