发明名称 Laser ablation electrospray ionization (LAESI) for atmospheric pressure, in vivo, and imaging mass spectrometry
摘要 The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
申请公布号 US8809774(B2) 申请公布日期 2014.08.19
申请号 US201313794851 申请日期 2013.03.12
申请人 The George Washington University 发明人 Vertes Akos;Nemes Peter
分类号 H01J49/26 主分类号 H01J49/26
代理机构 Fitch, Even, Tabin & Flannery LLP 代理人 Fitch, Even, Tabin & Flannery LLP
主权项 1. A laser ablation ionization device comprising: a pulsed, mid-infrared laser to emit energy at a sample to ablate the sample and generate an ablation plume; a translation stage comprising a sample holder, wherein the sample is in the sample holder; a focusing device to focus the laser energy onto a first side of the sample, wherein the ablation plume is generated on a second side of the sample; an electrospray apparatus to produce an electrospray to intercept the ablation plume and generate ions; and a mass spectrometer to detect the ions; wherein the laser energy has a wavelength at an absorption band of an OH group; and wherein the laser energy is coupled into the sample by water in the sample.
地址 Washington DC US