发明名称 |
Laser ablation electrospray ionization (LAESI) for atmospheric pressure, in vivo, and imaging mass spectrometry |
摘要 |
The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI). |
申请公布号 |
US8809774(B2) |
申请公布日期 |
2014.08.19 |
申请号 |
US201313794851 |
申请日期 |
2013.03.12 |
申请人 |
The George Washington University |
发明人 |
Vertes Akos;Nemes Peter |
分类号 |
H01J49/26 |
主分类号 |
H01J49/26 |
代理机构 |
Fitch, Even, Tabin & Flannery LLP |
代理人 |
Fitch, Even, Tabin & Flannery LLP |
主权项 |
1. A laser ablation ionization device comprising:
a pulsed, mid-infrared laser to emit energy at a sample to ablate the sample and generate an ablation plume; a translation stage comprising a sample holder, wherein the sample is in the sample holder; a focusing device to focus the laser energy onto a first side of the sample, wherein the ablation plume is generated on a second side of the sample; an electrospray apparatus to produce an electrospray to intercept the ablation plume and generate ions; and a mass spectrometer to detect the ions; wherein the laser energy has a wavelength at an absorption band of an OH group; and wherein the laser energy is coupled into the sample by water in the sample. |
地址 |
Washington DC US |