PROCESSO PARA A PREPARAÇÃO DE DERIVADOS SEMISSINTÉTICOS DE BETA-LACTAMA.

摘要

The present invention describes a process for the synthesis of a semi-synthetic beta-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.