| 主权项 |
1. A Compound of Formula (I′): or a pharmaceutically acceptable salt thereof, wherein A is —CH2—, —CHR5—, —CR5R6— or —CR5aR6a—CR5bR6b—; Ring C is a phenyl; R1 is C1-7alkyl, haloalkyl, C3-7cycloalkyl, C6-10aryl, C6-10aryl-C1-7alkyl, C6-10aryloxy-C1-7alkyl, heteroaryl or heterocyclyl in which alkyl, aryl, heteroaryl, heterocyclyl are optionally substituted with 1 to 5 R7; R2 is H, C1-7alkyl, halo-C1-7alkyl, C3-7cycloalkyl, C3-7cycloalkyl-C1-7alkyl, hydroxy-C1-7alkyl, C1-7alkyl-OC(O)C1-7alkyl, C1-7alkoxy-C1-7alkyl, heteroaryl, heterocycyl, or C6-10aryl; wherein aryl and heteroaryl are optionally substituted with hydroxy, C1-7alkoxy, C1-7alkyl, halo-C1-7alkyl, halo, CN or C3-7cycloalkyl; R3 is H, halo, C1-7alkyl, halo-C1-7alkyl, C3-7cycloalkyl, cyano, C1-7alkoxy, hydroxy, nitro, —NH2, —NH(C1-7alkyl) or —N(C1-7alkyl)2; two adjacent R4 groups form, with the atoms to which they are attached, a phenyl or a 5- or 6-membered ring heteroaryl, in which said phenyl or heteroaryl ring is optionally substituted with 1 to 4 R8; and each optional additional R4 is independently selected from the group consisting of halo, C1-7alkyl, halo-C1-7alkyl, C3-7cycloalkyl, cyano, —NH2, —NH(C1-7alkyl), —N(C1-7alkyl)2, C1-7alkoxy, halo-C1-7alkoxy, hydroxy, carboxy, nitro, sulfonyl, sulfamoyl, sulfonamido, C6-10aryl, heterocyclyl, C6-10aryloxy, heterocyclyloxy, —SH, —C(O)O—C6-10aryl, —C(O)O-heterocyclyl, —C(O)O-heteroaryl, —C(O)NR2— C1-7alkyl, —C(O)NR2—C6-10aryl, —C(O)NR2-heteroaryl, —C(O)NR2-heterocyclyl, —NR2C(O)—C1-7alkyl, —NR2C(O)—C6-10aryl, —NR2C(O)-heteroaryl, —NR2C(O)-heterocyclyl, —OC(O)—C1-7alkyl, —OC(O)—C6-10aryl, —OC(O)-heteroaryl and —OC(O)-heterocyclyl; wherein R4 is optionally substituted with 1 to 5 R7; R5 and R6 are independently C1-7alkyl, C3-7cycloalkyl, halo-C1-7alkyl, heterocyclyl, heteroaryl or C6-10aryl; or R5 and R6 form together with the atom to which they are attached a C3-7cycloalkyl; R5a, R6a, R5b and R6b are independently H, C1-7alkyl, C3-7cycloalkyl, halo-C1-7alkyl, heterocyclyl, heteroaryl or C6-10aryl; or any two of R5a, R6a, R5b and R6b form together with the atom(s) to which they are attached a C3-7cycloalkyl; each R7 is independently selected from the group consisting of halo, C1-7alkyl, C3-7cycloalkyl, C1-7alkoxy, C6-10aryloxy, heterocyclyl, C6-10aryl, heteroaryl, CN and halo-C1-7alkyl; each R8 is independently selected from the group consisting of halo, C1-7alkyl, halo-C1-7alkyl, C1-7alkoxy, CN and halo-C1-7alkoxy; or R2 and R3; R1 and R2; R1 and R5; R1 and R5a; R1 and R5b; R2 and R5a; R2 and R5b; R1 and R3; or R2 and R5 can form with the atoms to which they are attached a 4- to 7-membered heterocyclyl; or R3 and R5; R3 and R5b; or R3 and R5a can form together with the atoms to which they are attached a C5-7cycloalkyl; and
wherein each heteroaryl is a monocyclic aromatic ring comprising 5 or 6 ring atoms selected from carbon atoms and 1 to 5 heteroatoms, andeach heterocyclyl is a monocyclic saturated or partially saturated but non-aromatic moiety comprising 4-7 ring atoms selected from carbon atoms and 1 to 3 heteroatoms; and each heteroatoms being O, N or S; p is 2, 3, 4 or 5, with the proviso that the compound of Formula I′ is not 2-methyl-N-(6-(5-(phenylsulfonamido)pyridin-3-yl)-1H-indazol-4-yl)thiazole-4-carboxamide. |
