Balloon catheters having a plurality of needles for the injection of one or more therapeutic agents

摘要

There are disclosed apparatus and methods for treating tissue by delivering at least one therapeutic agent into the tissue. In one embodiment, the apparatus comprises a catheter and a balloon member disposed on a distal region of the catheter. A plurality of pockets are disposed on the balloon member, and a plurality of needles are associated with each of the plurality of pockets. The plurality of needles are configured to engage tissue when the balloon is in the inflated state, and further are configured to disperse a therapeutic agent from an associated pocket into the tissue when the balloon is in the inflated state. A first needle of the plurality of needles may comprise a length that is different than a second needle, permitting the delivery of first and second therapeutic agents to different depths within the tissue.

主权项

1. An apparatus for treating tissue at a target site, the apparatus comprising:
an inner cannula having proximal and distal regions and an inflation lumen disposed therein; an outer cannula having proximal and distal regions, wherein the outer cannula is disposed substantially co-axially over the inner cannula to form a delivery channel therebetween; an inner balloon member disposed on the distal region of the inner cannula, the inner balloon member having uninflated and inflated states; an outer balloon member disposed substantially over the inner balloon member; a plurality of pockets on a surface of the outer balloon member; and a plurality of needles, where at least one needle is associated with at least one of the plurality of pockets, where the inflation lumen is sized to receive an inflation fluid to inflate the inner balloon member and cause the plurality of needles to engage tissue, where each of the plurality of needles comprise openings sized to disperse a therapeutic agent, received via the delivery channel and the plurality of pockets, into the tissue, and where each of the plurality of pockets comprise a bulbous shape formed integrally into the outer balloon member.