Complexes comprising mammalian raptor polypeptide and mammalian mTOR polypeptide

摘要

The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.

主权项

1. An isolated complex comprising (i) comprising a polypeptide having an amino acid sequence at least 95% identical to SEQ ID NO: 2; and (ii) a mammalian mTOR polypeptide; wherein the polypeptide having an amino acid sequence at least 95% identical to SEQ ID NO:2, or the mTOR polypeptide, is fused to an epitope tag.