Drug delivery cuff

摘要

Embodiments provide a drug delivery cuff including a drug reservoir. In an embodiment, an integrated drug pump may be provided. A drug delivery cuff in accordance with an embodiment may be placed around any suitable vascular graft (e.g., ePTFE) or directly around any natural tissue conduit (e.g., perivascularly), at any position along the graft/conduit or overlapping a graft and conduit, either at the time of graft surgical placement or separate therefrom.

主权项

1. A cuff for the local delivery of a substance to a graft, comprising:
a reservoir for holding a drug-containing solution; a membrane between the reservoir and the graft, the membrane being microporous relative to the drug-containing solution; a pump provided to introduce the drug-containing solution to the reservoir at an infusion rate no greater than 1.0 ml/day and produce a threshold pressure within the reservoir wherein upon application of the threshold pressure the membrane releases the drug-containing solution from the reservoir to bloodstream within a lumen of the graft in a relatively uniform manner around an inner circumference of the membrane; and free ends that are configured to be engaged and disengaged from one another via a closure mechanism so as to respectfully attach and remove the cuff to and from the graft.