SUBSTITUTED PYRAZOLE AZETIDINES AS SPHINGOSINE RECEPTOR MODULATORS

摘要

The present invention relates to substituted pyrazole azetidines, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

主权项

1. A compound represented by Formula I, its enantiomers, diastereoisomers, tautomers, or a pharmaceutically acceptable salt thereof, wherein:
R1 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R2 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R3 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R4 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R5 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R6 is H, optionally substituted C6-10 aryl, optionally substituted heterocycle or optionally substituted C1-6 alkyl;R7 is H, OH or optionally substituted C1-6 alkyl;R8 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R9 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R10 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R11 is H, halogen or optionally substituted C1-6 alkyl, CN, NO2, C(O)R7, NR12R13 or OR14;R12 is H or optionally substituted C1-6 alkyl;R13 is H or optionally substituted C1-6 alkyl; andR14 is H or optionally substituted C1-6 alkyl.