| 发明名称 |
Use of ICOS-based CARs to enhance antitumor activity and CAR persistence |
| 摘要 |
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Thl7 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain. |
| 申请公布号 |
AU2013222288(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
AU20130222288 |
申请日期 |
2013.02.22 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
JUNE, CARL H.;GUEDAN CARRIO, SONIA;ZHAO, YANGBING;SCHOLLER, JOHN |
| 分类号 |
C07K14/705 |
主分类号 |
C07K14/705 |
| 代理机构 |
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代理人 |
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| 主权项 |
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