THIAZOLOPYRIDIN-2-YLOXY-PHENYL AND THIAZOLOPYRAZIN-2-YLOXY-PHENYL AMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE

摘要

PROBLEM TO BE SOLVED: To provide a synthesis method of amine E5, an intermediate of thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds, which are useful as leukotriene A4 hydrolase (LTA4H) modulators.SOLUTION: Acetylation/reduction of oxime E4is performed.