17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

摘要

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds of the present invention have been found to be useful as 17α-hydroxylase/C17,20-lyase inhibitors.;

主权项

1. A compound of Formula (I)wherein
R1 is (i) phenyl optionally substituted with 1 to 3 substituents selected from halo, —CN, —OH, (C1-C6)alkyl, halo-substituted (C1-C6)alkyl, (C1-C6)alkoxy, —NH2, —NH(C1-C4)alkyl, —N((C1-C4)alkyl)2, —NHC(O)—(C1-C4)alkyl, —C(O)NH2, —C(O)—NH(C1-C4)alkyl, —C(O)—N((C1-C4)alkyl)2, (C3-C5)cycloalkyl, or a 5- to 6-membered heterocycle, (ii) phenyl fused to an additional phenyl, a 5- to 6-membered heteroaryl, a 5- to 6-membered partially or fully saturated cycloalkyl, or a 5- to 6-membered partially or fully saturated heterocycle, where said fused phenyl is optionally substituted with 1 to 4 substituents each independently selected from halo, —CN, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy-substituted (C1-C4)alkyl, halo-substituted (C1-C4)alkyl, (C3-C5)cycloalkyl, oxo, —NH2, —NH(C1-C4)alkyl, —N((C1-C4)alkyl)2, —NHC(O)—(C1-C4)alkyl, or ═N—OH, (iii) 5- to 6-membered heteroaryl optionally substituted with 1 to 3 substituents each independently selected from halo, —CN, —OH, (C1-C6)alkyl, halo-substituted (C1-C6)alkyl, (C1-C6)alkoxy, —NH2, —NH(C1-C4)alkyl, —N((C1-C4)alkyl)2, —NHC(O)—(C1-C4)alkyl, —C(O)NH2, —C(O)—NH(C1-C4)alkyl, —C(O)—N((C1-C4)alkyl)2, (C3-C5)cycloalkyl, or a 5- to 6-membered heterocycle, or (iv) 5- to 6-membered heteroaryl fused to another 5- to 6-membered heteroaryl, phenyl, 5- to 6-membered partially or fully saturated cycloalkyl, or a 5- to 6-membered partially or fully saturated heterocycle, where said fused heteroaryl is optionally substituted with 1 to 4 substituents each independently selected from halo, —CN, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy-substituted (C1-C4)alkyl, halo-substituted (C1-C4)alkyl, (C3-C5)cycloalkyl, oxo, —NH2, —NH(C1-C4)alkyl, —N((C1-C4)alkyl)2, —NHC(O)—(C1-C4)alkyl, or ═N—OH; R2 and R5 are each independently CH3 or H; R3 and R4 are each independently CH3 or H, or taken together with the carbon atoms to which they are attached form a cyclopropyl; and R6 is (C3-C5)cycloalkyl, where the cycloalkyl is optionally substituted with hydroxy; or a pharmaceutically acceptable salt thereof.