T CELL RECEPTOR AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a T cell receptor capable of recognizing both a state where wild type WT1 specific peptide is presented by HLA-A*24:02 and a state where variant WT1 specific peptide is presented by HLA-A*24:02; and a DNA coding the T cell receptor.SOLUTION: A method for efficient proliferation and culture of WT1 peptide specific CTL under limiting dilution conditions was developed. Using this method, CTL capable of recognizing both a state where wild type WT1 specific peptide is presented by HLA-A*24:02 and a state where variant WT1 specific peptide is presented by HLA-A*24:02 was successfully acquired.