HUMAN HEPATOCYTE-LIKE CELLS AND USES THEREOF

摘要

A method for generating human hepatocyte-like cells is provided, comprising (i) forcing expression of a FOXA polypeptide and a HNF polypeptide in a non-hepatic human cell, and (ii) culturing the non-hepatic human cell in a medium for a period of time to obtain one or more progeny cells. Also provided is a cultured hepatocyte-like cell obtained using the method and a pharmaceutical composition comprising the same and a pharmaceutically acceptable carrier.