| 发明名称 |
SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS |
| 摘要 |
The present invention relates to compounds of the formula (I) and in particular medicaments comprising at least one compound of the formula (I) for use in the treatment and/or prophylaxis of physiological and/or pathophysiological states in the triggering of which ADAMTS5 is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, hepatocirrhosis, traumatic cartilage injuries, pain, allodynia or hyperalgesia. |
| 申请公布号 |
WO2014121884(A1) |
申请公布日期 |
2014.08.14 |
| 申请号 |
WO2014EP00100 |
申请日期 |
2014.01.16 |
| 申请人 |
MERCK PATENT GMBH |
发明人 |
KLEIN, MARKUS;LINDEMANN, SVEN |
| 分类号 |
C07D213/81;A61P19/00;C07C233/83;C07D211/34;C07D213/40;C07D213/56;C07D213/82;C07D233/64;C07D241/12;C07D241/24;C07D277/30;C07D277/56;C07D295/18;C07D305/08 |
主分类号 |
C07D213/81 |
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