发明名称 |
ANTIBODY SUBSTITUTING FOR FUNCTION OF BLOOD COAGULATION FACTOR VIII |
摘要 |
<p>The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.</p> |
申请公布号 |
EP1876236(B1) |
申请公布日期 |
2014.08.13 |
申请号 |
EP20060730769 |
申请日期 |
2006.03.31 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
KOJIMA, TETSUO;HATTORI, KUNIHIRO;SOEDA, TETSUHIRO;MIYAZAKI, TARO;SAITO, HIROYUKI |
分类号 |
C12N15/09;A61K39/395;A61P7/04;C07K16/40;C07K16/46 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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