| 发明名称 |
SUBSTITUTED AMINOPROPIONIC DERIVATIVES AS NEPRILYSIN INHIBITORS |
| 摘要 |
<p>The present invention provides a compound of formula I';
or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , B 1 , X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.</p> |
| 申请公布号 |
EP2435409(B1) |
申请公布日期 |
2014.08.13 |
| 申请号 |
EP20100720165 |
申请日期 |
2010.05.26 |
| 申请人 |
NOVARTIS AG |
发明人 |
COPPOLA, GARY MARK;IWAKI, YUKI;KARKI, RAJESHRI GANESH;KAWANAMI, TOSHIO;KSANDER, GARY MICHAEL;MOGI, MUNETO;SUN, ROBERT |
| 分类号 |
C07D213/82;A61K31/21;A61K31/435;C07C233/47;C07D239/36;C07D261/18;C07D271/06 |
主分类号 |
C07D213/82 |
| 代理机构 |
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