| 发明名称 |
ETHYNYL DERIVATIVES AS MGLUR5 ALLOSTERIC MODULATORS |
| 摘要 |
<p>The present invention relates to ethynyl derivatives of formula I wherein U, V, Y, R1, R2, R2′, R3, R3′and R8 are described herein. It has been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).</p> |
| 申请公布号 |
EP2763977(A1) |
申请公布日期 |
2014.08.13 |
| 申请号 |
EP20120767005 |
申请日期 |
2012.10.04 |
| 申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
JAESCHKE, GEORG;LINDEMANN, LOTHAR;RICCI, ANTONIO;RUEHER, DANIEL;STADLER, HEINZ;VIEIRA, ERIC |
| 分类号 |
C07D401/04;A61K31/4439;A61K31/506;A61P25/08;A61P25/18;A61P25/28;C07D403/04;C07D413/04 |
主分类号 |
C07D401/04 |
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