发明名称 |
Detection method for intermolecular interaction and detection device thereof |
摘要 |
In order to calculate and specify a valley wavelength easily and in a short period of time, a detection device for intermolecular interaction is disclosed that is equipped with a detector provided with a ligand, a white light source that irradiates the detector with white light, a spectrometer that detects the light reflected from the detector, and a control device that controls the white-light source and the spectrometer, wherein the aforementioned control device obtains a reflection spectrum by calculating the reflectivity over a fixed wavelength interval, approximates the aforementioned reflection spectrum as a high-dimensional function, selects a wavelength interval comprising the minimum reflectivity from the aforementioned high-dimensional function, approximates the aforementioned high-dimensional function with the aforementioned wavelength interval as a quadratic function of a lower order, and obtains a solution by which the aforementioned quadratic function is differentiated with respect to the wavelength and the value thereof becomes 0. |
申请公布号 |
US8804125(B2) |
申请公布日期 |
2014.08.12 |
申请号 |
US201113583612 |
申请日期 |
2011.02.10 |
申请人 |
Konica Minolta, Inc. |
发明人 |
Kashiwazaki Osamu;Izumiya Naoki;Atarashi Yuichi |
分类号 |
G01N21/00;G01N21/55 |
主分类号 |
G01N21/00 |
代理机构 |
Holtz Holtz Goodman & Chick PC |
代理人 |
Holtz Holtz Goodman & Chick PC |
主权项 |
1. A detection method for an intermolecular interaction comprising:
a step of shining light on a ligand; a step of measuring, by a spectrometer, light reflected by the ligand; a step of calculating, by a control device from the reflected light, a reflectance over a fixed wavelength interval to obtain a reflectance spectrum; a step of approximating, by the control device, the reflectance spectrum by a high-dimensional function; a step of selecting, by the control device, a wavelength interval having a minimum reflectance from the high-dimensional function; a step of approximating, by the control device in the wavelength interval, the high-dimensional function by a quadratic function, which is lower order than the high-dimensional function; a step of differentiating, by the control device, the quadratic function with respect to the wavelength to obtain a solution in which a value thereof becomes zero; and a step of generating, by the control device from the solution, an output signal indicating a bottom peak wavelength. |
地址 |
Tokyo JP |