发明名称 Compounds for reducing drug resistance and uses thereof
摘要 This invention provides compounds capable of reducing drug resistance in a subject undergoing cancer treatment, methods using the compounds, compositions, and methods for identifying such compounds.
申请公布号 US8802702(B2) 申请公布日期 2014.08.12
申请号 US201013144228 申请日期 2010.01.15
申请人 The General Hospital Corporation 发明人 Duan Zhenfeng;Hornicek Francis J.
分类号 A61K31/47 主分类号 A61K31/47
代理机构 Fish & Richardson P.C. 代理人 Fish & Richardson P.C.
主权项 1. A method of reducing drug resistance in a subject undergoing cancer treatment with administration of a chemotherapeutic drug, wherein the cancer is selected from the group consisting of: breast, respiratory tract, brain, reproductive organs, digestive tract, urinary tract, eye, liver, head and neck, thyroid, parathyroid, a distant metastasis of a solid tumor, lymphoma, sarcoma, and leukemia, said method comprising administering to a subject in need thereof an effective amount of (2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol or a pharmaceutically acceptable salt thereof, wherein (2-(4-methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol or a pharmaceutically acceptable salt thereof is administered at a dose that is lower than the dose required to produce cytotoxicity in said subject, thereby reducing drug resistance in said subject.
地址 Boston MA US