Substituted acetyl-coa carboxylase inhibitors

摘要

The invention provides a compound of Formula (I);
or a pharmaceutically acceptable salt thereof; wherein
G is;R1, R2 and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl-CoA carboxylase enzyme(s) in an animal.

主权项

1. A compound selected from the group consisting of
6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; 6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide; 1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-1-isopropyl-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide; N-ethyl-5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide; 6-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrazolo[3,4-b]pyridine-3-carboxamide; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide; 1-isopropyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-1,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one; 5-[(1-isopropyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-benzimidazole-2-carboxamide; 5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(1-tert-butyl-7-oxo-1,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide; 6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-3-carboxamide; 6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-indole-2-carboxamide; 1′-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2-tert-butyl-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-ethyl-1H-indazole-3-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-methyl-1H-indazole-3-carboxamide; 5-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-N-(2,2,2-trifluoroethyl)-1H-indazole-3-carboxamide; 2-tert-butyl-1′-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2,4-dihydrospiro[indazole-5,4′-piperidin]-7(6H)-one; 6-[(2-tert-butyl-7-oxo-2,4,6,7-tetrahydro-1′H-spiro[indazole-5,4′-piperidin]-1′-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; 6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide; 6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide; 6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide; 5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indazole-3-carboxamide; 5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-2-carboxamide; 5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-indole-3-carboxamide; 5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide; 1-[(2-amino-1H-benzimidazol-5-yl)carbonyl]-2′-tert-butyl-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one; 2′-tea-butyl-1-{[2-(methylamino)-1H-benzimidazol-5-yl]carbonyl}-2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-7′(6′H)-one; 6-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-pyrrolo[3,2-b]pyridine-3-carboxamide; and 5-[(2′-tert-butyl-7′-oxo-6′,7′-dihydro-1H,2′H-spiro[piperidine-4,5′-pyrano[3,2-c]pyrazol]-1-yl)carbonyl]-1H-benzimidazole-2-carboxamide;or a pharmaceutically acceptable salt thereof.