Macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages

摘要

Disclosed is a highly effective macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages using an active component derived from natural products. A culture obtained by culturing microorganisms belonging to the genus Aureobasidium (Aureobasidium sp.) is used as the active component of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages. By means of the macrophage phagocytosis-activating composition and/or composition promoting cytokine production in macrophages, macrophage phagocytosis can be activated, and cytokine production in macrophages can be promoted. In particular, a macrophage phagocytosis-activating composition can activate the phagocytosis of cancer cells or cells damaged or destroyed by anticancer drugs.

主权项

1. A method for activating macrophage phagocytosis by macrophages or macrophage-like cells or promoting cytokine production in macrophages or macrophage-like cells, comprising:
(a) obtaining a culture by culturing a microorganism belonging to Aureobasidium sp.; and (b) administering to the macrophages or macrophage-like cells a composition comprising said culture and compound (1)wherein the microorganism belonging to Aureobasidium sp. is Aureobasidium pullulans M-1 (FERM BP-08615), wherein the composition comprises Compound 1 at 10 μM, wherein the composition is in an amount effective for activating macrophage phagocytosis synergistically by the macrophages or macrophage-like cells or promoting cytokine production synergistically in macrophages or macrophage-like cells.