| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compounds or their pharmaceutically acceptable salts, where compound has formula1-a, in which Rand Rare absent, m represents integer number from 1 to 2, n represents integer number from 1 to 3, A represents, B representsor, where Xrepresents O or S, Ris absent, Ris selected from the group, consisting of:,,,,and; Ris selected from Calkyl and Chalogenalkyl, L and E are such as given in i.1 of the invention formula; or compound is such as given in b) of i.1 of the invention formula. Invention also relates to pharmaceutical composition, which contains said compounds.EFFECT: compounds by i1, possessing inhibiting activity with respect to anti-apoptosis protein Bcl-X.27 cl, 6 dwg, 2 tbl, 126 ex |
