| 主权项 |
1: A compound of formula I: wherein: A iswherein each Z3a is independently selected from H or Z3;
R1 is heteroaryl, wherein the heteroaryl of R1 is a bicyclic-heteroaryl or tricyclic-heteroaryl, wherein the bicyclic-heteroaryl or tricyclic-heteroaryl has 4-9 carbon atoms and 1-5 heteroatoms and wherein the heteroaryl of R1 is optionally substituted with 1, 2, 3, 4, or 5 Z4 groups; R2 is phenyl, 5-membered heteroaryl, 6-membered heteroaryl or (C3-C7)carbocycle wherein any phenyl, 5-membered heteroaryl, 6-membered heteroaryl or (C3-C7)carbocycle of R2 is optionally substituted with 1, 2, or 3 Z5 groups; each R3a and R3b is independently selected from H, halogen, (C1-C3)alkyl, and (C1-C3)haloalkyl, or R3a is selected from H, (C1-C3)alkyl and (C1-C3)haloalkyl and R3b is selected from —OH and —CN; Z1 is phenyl, monocyclic-heteroaryl or bicyclic-heterocycle, wherein the monocyclic-heteroaryl or bicyclic-heterocycle has 2-12 carbon atoms and 1-5 heteroatoms and, wherein any phenyl, monocyclic-heteroaryl or bicyclic-heterocycle of Z1 is optionally substituted with 1, 2, 3, 4, or 5 Z1a or Z1b; each Z1a is independently selected from (C3-C7)carbocycle, (C6-C20) aryl, heteroaryl, heterocycle, halogen, —CN, —ORn1, —OC(O)Rp1, —OC(O)NRq1Rr1, —SRn1, —S(O)Rp1, —S(O)2OH, —S(O)2Rp1, —S(O)2NRq1Rr1, —NRq1Rr1, —NRn1CORp1, —NRn1CO2Rp1, —NRn1CONRq1Rr1, —NRn1S(O)2Rp1, —NRn1S(O)2ORp1, —NRn1S(O)2NRq1Rr1, NO2, —C(O)Rn1, —C(O)ORn1, —C(O)NRq1Rr1 and —S(O)2NRn1CORp1, wherein any heteroaryl of Z1a has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Z1a has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Z1a is optionally substituted with 1, 2, 3, 4, or 5 Z1c or Z1d groups; each Z1b is independently selected from (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl, wherein any (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl of Z1b is optionally substituted with 1, 2, 3, 4, or 5 Z1c groups; each Z1c is independently selected from (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, heterocycle, halogen, —CN, —ORn2, —OC(O)Rp2, —OC(O)NRq2Rr2, —SRn2, —S(O)Rp2, —S(O)2OH, —S(O)2Rp2, —S(O)2NRq2Rr2, —NRq2Rr2, —NRn2CORp2, —NRn2CO2Rp2, —NRn2CONRq2Rr2, —NRn2S(O)2Rp2, —NRn2S(O)2ORp2, —NRn2S(O2NRq2Rr2, NO2, —C(O)Rn2, —C(O)ORn2, —C(O)NRq2Rr2, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle and (C1-C8)heteroalkyl, wherein any heteroaryl or haloheteroaryl of Z1c has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Z1c has 2-20 carbon atoms and 1-6 heteroatoms; each Z1d is independently selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl and (C1-C8)haloalkyl; each Rn1 is independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rn1 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rn1 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rn1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c or Z1d groups, and wherein any (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl of Rn1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c groups; each Rp1 is independently selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rp1 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rp1 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rp1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c or Z1d groups, and wherein any (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl of Rp1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c groups; Rq1 and Rr1 are each independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rq1 and Rr1 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rq1 and Rr1 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c or Z1d groups, and wherein any (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl of Rq1 or Rr1 is optionally substituted with 1, 2, 3, 4, or 5 Z1c groups, or Rq1 and Rr1 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z1c or Z1d groups; each Rn2 is independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C8)haloalkyl and (C1-C8)heteroalkyl, wherein any heteroaryl or haloheteroaryl Of Rn2 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle Of Rn2 has 2-20 carbon atoms and 1-6 heteroatoms; each Rp2 is independently selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C8)haloalkyl and (C1-C8)heteroalkyl, wherein any heteroaryl or haloheteroaryl of Rp2 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Rp2 has 2-20 carbon atoms and 1-6 heteroatoms; Rq2 and Rr2 are each independently selected from H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C8)haloalkyl and (C1-C8)heteroalkyl, or Rq2 and Rr2 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein any heteroaryl or haloheteroaryl of Rq2 and Rr2 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Rq2 and Rr2 has 2-20 carbon atoms and 1-6 heteroatoms; Z2 is selected from —ORs3, —OC(O)Rp3, —OC(O)NRq3Rr3, —SRn3, —S(O)Rp3, —S(O)2Rp3, —S(O)2NRq3Rr3, —NRq3Rr3, —NRn3CORp3, —NRn3CO2Rp3, —NRn3S(O)2Rp3, —NRn3S(O)2ORp3 and —NRn3S(O)2NRq3Rr3; each Z2a is independently selected from (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, heterocycle, halogen, —CN, —ORn4, —OC(O)Rp4, —OC(O)NRq4Rr4, —SRn4, —S(O)Rp4, —S(O)2OH, —S(O)2Rp4, —S(O)2NRq4Rr4, —NRq4Rr4, —NRn4CORp4, —NRn4CO2Rp4, —NRn4CONRq4Rr4, —NRn4S(O)2Rp4, —NRn4S(O)2ORp4, —NRn4S(O)2NRq4Rr4, NO2, —C(O)Rn4, —C(O)ORn4, —C(O)NRq4Rr4, wherein any heteroaryl of Z2a has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Z2a has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Z2a is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups; each Z2b is independently selected from (C1-C4)alkyl, (C1-C4)heteroalkyl and (C1-C4)haloalkyl; each Z2c is independently selected from halogen, —CN, —ORn4, —OC(O)Rp4, —OC(O)NRq4Rr4, —SRn4, —S(O)Rp4, —S(O)2OH, —S(O)2Rp4, —S(O)2NRq4Rr4, —NRq4Rr4, —NRn4CORp4, —NRn4CO2Rp4, —NRn4CONRq4Rr4, —NRn4S(O)2Rp4, —NRn4S(O)2ORp4, —NRn4S(O)2NRq4Rr4, NO2, —C(O)Rn4, —C(O)ORn4, —C(O)NRq4Rr4; each Rn3 is independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rn3 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rn3 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rn3 is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl of Rn3 is optionally substituted with 1, 2, 3, 4, or 5 Z2a groups; each Rp3 is independently selected from (C1-C4)alkyl, (C1-C4)haloalkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rp3 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rp3 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rp3 is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rp3 is optionally substituted with 1, 2, 3, 4, or 5 Z2a groups; Rq3 and Rr3 are each independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rq3 or Rr3 is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups, and wherein any (C1-C4)alkyl and (C2-C4)alkenyl of Rq3 or Rr3 is optionally substituted with 1, 2, 3, 4, or 5 Z2a groups, or Rq3 and Rr3 together with the nitrogen to which they are attached form a heterocycle or heteroaryl, wherein the heterocycle or heteroaryl is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups, wherein any heteroaryl of Rq3 and Rr3 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rq3 and Rr3 has 2-20 carbon atoms and 1-6 heteroatoms; each Rs3 is independently selected from (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rs3 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rs3 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rs3 is optionally substituted with 1, 2, 3, 4, or 5 Z2b or Z2c groups, and wherein any (C2-C4)alkenyl or (C2-C4)alkynyl of Rs3 is optionally substituted with 1, 2, 3, 4, or 5 Z2a groups, or Rs3 is (C1-C4)alkyl substituted with 1, 2, 3, 4, or 5 Z2a groups; each Rn4 is independently selected from H, (C1-C4)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C1-C4)haloalkyl and (C1-C4)heteroalkyl; each Rp4 is independently selected from (C1-C8)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)haloalkyl and (C1-C4)heteroalkyl; Rq4 and Rr4 are each independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)haloalkyl and (C1-C4)heteroalkyl; each Z3 is independently selected from halogen, (C1-C4)alkyl, —OH, —CN, (C1-C4)heteroalkyl and (C1-C4)haloalkyl; each Z4 is independently selected from (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, heterocycle, halogen, —CN, —ORn5, —OC(O)Rp5, —OC(O)NRq5Rr5, —SRn5, —S(O)Rp5, —S(O)2OH, —S(O)2Rp5, —S(O)2NRq5Rr5, —NRq5Rr5, —NRn5CORp5, —NRn5CO2Rp5, —NRn5CONRq5Rr5, —NRn5S(O)2Rp5, —NRn5S(O)2ORp5, —NRn5S(O)2NRq5Rr5, NO2, —C(O)Rn5, —C(O)ORn5, —C(O)NRq5Rr5 and —B(ORq5)(ORr5), wherein any heteroaryl of Z4 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Z4 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Z4 is optionally substituted with 1, 2, 3, 4, or 5 Z4a or Z4b groups, and wherein any (C1-C8)alkyl, (C2-C8)alkenyl and (C2-C8)alkynyl of Z4 is optionally substituted with 1, 2, 3, 4, or 5 Z4a groups; each Z4a is independently selected from (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, heterocycle, halogen, —CN, —ORn6, —OC(O)Rp6, —OC(O)NRp6Rr6, —SRn6, —S(O)Rp6, —S(O)2OH, —S(O)2Rp6, —S(O)2NRq6Rr6, —NRq6Rr6, —NRn6CORp6, —NRn6CO2Rp6, —NRn6CONRq6Rr6, —NRn6S(O)2Rp6, —NRn6S(O)2ORp6, —NRn6S(O)2NRq6Rr6, NO2, —C(O)Rn6, —C(O)ORn6, and —C(O)NRq6Rr6, wherein any heteroaryl of Z4a has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Z4a has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Z4a is optionally substituted with 1, 2, 3, 4, or 5 Z4c or Z4d groups; each Z4b is independently selected from (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl, wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Z4b is optionally substituted with 1, 2, 3, 4, or 5 Z4c groups; each Z4c is independently selected from (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, heterocycle, halogen, —CN, —ORn7, —OC(O)Rp7, —OC(O)NRq7Rr7, —SRn7, —S(O)Rp7, —S(O)2OH, —S(O)2Rp7, —S(O)2NRq7Rr7, —NRq7Rr7, —NRn7CORp7, —NRn7CO2Rp7, —NRn7CONRq7Rr7, —NRn7S(O)2Rp7, —NRn7S(O)2ORp7, —NRn7S(O)2NRq7Rr7, NO2, —C(O)Rn7, —C(O)ORn7, —C(O)NRq7Rr7, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle and (C1-C4)heteroalkyl, wherein any heteroaryl or haloheteroaryl of Z4c has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Z4c has 2-20 carbon atoms and 1-6 heteroatoms; each Z4d is independently selected from (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, and (C1-C4)haloalkyl; each Rn5 is independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rn5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a or Z4b groups, wherein any heteroaryl of Rn5 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rn5 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rn5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a groups; each Rp5 is independently selected from (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rp5 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rp5 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl, or heterocycle of Rp5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a or Z4b groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl or (C2-C4)alkynyl of Rp5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a groups; Rq5 and Rr5 are each independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rq5 or Rr5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a or Z4b groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rq5 or Rr5 is optionally substituted with 1, 2, 3, 4, or 5 Z4a groups, or Rq5 and Rr5 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z4a or Z4b groups, wherein any heteroaryl of Rq5 and Rr5 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rg5 and Rr5 has 2-20 carbon atoms and 1-6 heteroatoms; each Rn6 is independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rn6 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rn6 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rn6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c or Z4d groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rn6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c groups; each Rp6 is independently selected from (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rp6 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rp6 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rp6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c or Z4d groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rp6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c groups; Rq6 and Rr6 are each independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl and (C6-C20)aryl, wherein any heteroaryl of Rq6 and Rr6 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle of Rq6 and Rr6 has 2-20 carbon atoms and 1-6 heteroatoms and wherein any (C3-C7)carbocycle, (C6-C20)aryl, heteroaryl and heterocycle of Rq6 or Rr6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c or Z4d groups, and wherein any (C1-C4)alkyl, (C2-C4)alkenyl and (C2-C4)alkynyl of Rq6 or Rr6 is optionally substituted with 1, 2, 3, 4, or 5 Z4c groups, or Rq6 and Rr6 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein the 5, 6 or 7-membered heterocycle is optionally substituted with 1, 2, 3, 4, or 5 Z4c or Z4d groups; each Rn7 is independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C4)haloalkyl and (C1-C4)heteroalkyl, wherein any heteroaryl or haloheteroaryl Of Rn7 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle Of Rn7 has 2-20 carbon atoms and 1-6 heteroatoms; each Rp7 is independently selected from (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C4)haloalkyl and (C1-C4)heteroalkyl, wherein any heteroaryl or haloheteroaryl of Rp7 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Rp7 has 2-20 carbon atoms and 1-6 heteroatoms; Rq7 and Rr7 are each independently selected from H, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C3-C7)carbocycle, heterocycle, heteroaryl, (C6-C20)aryl, (C6-C20)haloaryl, haloheteroaryl, haloheterocycle, (C1-C4)haloalkyl and (C1-C4)heteroalkyl, or Rq7 and Rr7 together with the nitrogen to which they are attached form a 5, 6 or 7-membered heterocycle, wherein any heteroaryl or haloheteroaryl of Rq7 and Rr7 has 1-20 carbon atoms and 1-6 heteroatoms and wherein any heterocycle or haloheterocycle of Rq7 and Rr7 has 2-20 carbon atoms and 1-6 heteroatoms; each Z5 is independently selected from (C1-C6)alkyl, halogen, —CN, and —ORn8, wherein any (C1-C6)alkyl of Z5 is optionally substituted with 1, 2, 3, 4, or 5 halogen; and each Rn8 is independently selected from H, (C1-C3)alkyl, (C1-C3)haloalkyl and (C3-C7)carbocycle; or a salt thereof. |
