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1. A method of modulating a chemokine receptor activity comprising administering an effective amount of a pyrazolopyrimidine derivative represented by the formula (I) [wherein R1 represents —NR1aR1b (wherein R1a and R1b are the same or different and each represents a hydrogen atom, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), lower alkanoyl optionally having substituent(s), aryl optionally having substituent(s), aralkyl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s), or R1a and R1b form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), —OR1c (wherein R1c represents a hydrogen atom, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), aryl optionally having substituent(s), aralkyl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s)) or —SR1d (wherein R1d has the same definition as the above R1c), R2 represents [wherein k and m each represents an integer of 0 to 2 (provided that, the total of k and m is less than or equal to 3), n represents an integer of 0 to 4, and when n is 2, 3 or 4, respective R5s may be the same or different, L represents a single bond, alkylene, C(═O) or SO2, R5 represents halogen, hydroxy, lower alkyl optionally having substituent(s) or lower alkoxy optionally having substituent(s), R6 represents lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), aryl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s), X represents a nitrogen atom or —CR8 (wherein R8 represents a hydrogen atom, halogen, hydroxy, cyano, lower alkyl optionally having substituent(s) or lower alkoxy optionally having substituent(s), or forms a bond together with R7), and R7 forms a bond together with R8, or represents a hydrogen atom, halogen, hydroxy, lower alkyl optionally having substituent(s) or lower alkoxy optionally having substituent(s)], {wherein ka, ma and na have the same definitions as the above k, m and n, respectively, R5a has the same definition as the above R5, represents a single bond or a double bond, R9a and R9b are the same or different and each represents a hydrogen atom or lower alkyl optionally having substituent(s), or R9a and R9b form, together with the respectively adjacent carbon atoms, an aliphatic ring optionally having substituent(s) or an aromatic ring optionally having substituent(s), and Y represents —CHR10a—CHR10b— (wherein, R10a and R10b are the same or different and each represents a hydrogen atom, hydroxy, lower alkyl optionally having substituent(s) or lower alkoxy optionally having substituent(s), or R10a and R10b form, together with the respectively adjacent carbon atoms, an aliphatic ring optionally having substituent(s)), —CR10c CR10d— (wherein, R10c and R10d are the same or different and each represents a hydrogen atom or lower alkyl optionally having substituent(s), or R10c and R10d form, together with the respectively adjacent carbon atoms, an aliphatic ring having at least one double bond and optionally having substituent(s) or an aromatic ring optionally having substituent(s)), —Za—CR11aR11b [wherein R11a and R11b are the same or different and each represents a hydrogen atom or lower alkyl optionally having substituent(s), or R11a and R11b form carbonyl together with the adjacent carbon atom, and Za represents C(═O), O, S, SO, SO2 or NR12 (wherein R12 represents a hydrogen atom, lower alkyl optionally having substituent(s), lower alkanoyl optionally having substituent(s), lower alkoxycarbonyl optionally having substituent(s) or aralkyl optionally having substituent(s))], or —CR11cR11d—Zb (wherein R11c, R11d and Zb have the same definitions as the above R11a, R11b and Za, respectively)}, or (wherein Rz represents lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), aryl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s), R5b and R7b are the same or different and each represents halogen, hydroxy, lower alkyl optionally having substituent(s) or lower alkoxy optionally having substituent(s), nb represents an integer of 0 to 2, when nb is 2, respective R5bs are the same or different, and nc represents an integer of 0 to 2, when nc is 2, respective es are the same or different), R3 represents —S(O)2R13a [wherein R13a represents hydroxy, N,N-di-lower alkylaminomethyleneamino, lower alkoxy optionally having substituent(s), —NR13bR13c (wherein R13b and R13c are the same or different and each represents a hydrogen atom, lower alkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), cycloalkyl optionally having substituent(s), aralkyl optionally having substituent(s), aryl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s), or R13b and R13c form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group optionally having substituent(s)), —NR13dC(═O)R13e (wherein R13d represents a hydrogen atom, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), aralkyl optionally having substituent(s), aryl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s), and R13e represents a hydrogen atom, amino, lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), aralkyl optionally having substituent(s), lower alkoxy optionally having substituent(s), N-mono-lower alkylamino optionally having substituent(s), N,N-di-lower alkylamino optionally having substituent(s), N-cycloalkylamino optionally having substituent(s), N-mono-arylamino optionally having substituent(s), N,N-di-arylamino optionally having substituent(s), aryl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s)), —NR13fC(═S)R13g(wherein R13f and R13g have the same definitions as the above R13d and R13e, respectively) or —NR13hS(O)2R14 (wherein R13h has the same definition as the above R13d, and R14 represents lower alkyl optionally having substituent(s), cycloalkyl optionally having substituent(s), N-mono-lower alkylamino optionally having substituent(s), N,N-di-lower alkylamino optionally having substituent(s), aryl optionally having substituent(s), aralkyl optionally having substituent(s), an aromatic heterocyclic group optionally having substituent(s) or an aliphatic heterocyclic group optionally having substituent(s))], and R4 represents a hydrogen atom, halogen, lower alkyl optionally having substituent(s), aralkyl optionally having substituent(s), —NR15aR15b (wherein R15a and R15b have the same definitions as the above R1a and R1b, respectively), —OR15c (wherein R15c has the same definition as the above R1c), or —SR15d (wherein R15d has the same definition as the above R1c)], or a pharmaceutically acceptable salt thereof, as an active ingredient. |
