| 摘要 |
PROBLEM TO BE SOLVED: To provide a medicine, a functional food, or a food additive comprising γ-oryzanol as an active ingredient which suppresses enhancement of endoplasmic reticulum stress or glucagon secretion and facilitates insulin secretion by affecting pancreas directly not via central nervous system.SOLUTION: Disclosed are an endoplasmic-reticulum-stress enhancement inhibitor, an insulin secretion promoter, and a glucagon secretion inhibitor comprising γ-oryzanol as an active ingredient which affect to suppress impaired insulin secretion caused by endoplasmic-reticulum-stress enhancement in pancreas, facilitate insulin secretion from pancreas, and suppress glucagon secretion from pancreas by administering orally 20 or more μg/g body weight per day. |
