SYSTEMS AND METHODS FOR QUANTIFICATION AND PRESENTATION OF MEDICAL RISK ARISING FROM UNKNOWN FACTORS

摘要

Example methods of quantifying known and unknown risks of an adverse drug event in an individual based on various factors are disclosed. In some embodiments, factors include known drug-drug interactions and unknown phenotypes of cytochromes. Quantification may be based on severity of the adverse drug event/and or probability of occurrence in some embodiments. Example methods of displaying the quantified risk are also disclosed. In one embodiment, the risk of individuals is aggregated to display the risk of a population.

主权项

1. A method comprising:
receiving, at a computing system, identification of at least one drug; selecting, using the computing system, certain factors affecting exposure of an individual to the at least one drug, wherein at least one of the factors comprises a genotype, wherein at least one of the certain factors are known factors for the individual and at least one of the certain factors are unknown factors for the individual; quantifying, using the computing system, a first expected effect on metabolism of the drug by the patient due to the known factors and quantifying, using the computing system, a second expected effect on metabolism of the drug by the individual due to the known factors and the unknown factors.