MEASURING EMBRYO DEVELOPMENT AND IMPLANTATION POTENTIAL WITH TIMING AND FIRST CYTOKINESIS PHENOTYPE PARAMETERS

摘要

Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.

主权项

1. A method for deselecting one or more human embryos with poor developmental potential comprising:
(A) in vitro culturing one or more embryos under conditions sufficient for embryo development; (B) time lapse imaging said one or more embryos for a time period sufficient to measure at least one cell division; and (C) deselecting an embryo with poor developmental potential when, the embryo displays abnormal cleavage (AC) thereby deselecting an embryo with poor developmental potential, wherein the embryo with poor developmental potential is not likely to reach the blastocyst stage or successfully implant into the uterus.