SYSTEM AND METHOD FOR MULTIPLEX SPECTROSCOPIC IMAGING

摘要

A system for measuring an sample includes an illumination source providing electromagnetic radiation pulses at a selected temporal frequency. A microscope focuses the radiation to interact with the sample and produce resultant electromagnetic radiation. A disperser disperses wavelengths of the resultant radiation onto optical sensors, and respective resonant amplifiers amplify signals having the selected temporal frequency. Optical detection apparatus includes the optical sensors, resonant amplifiers, and disperser. The resonant amplifiers amplify portion(s) of their inputs having a selected temporal frequency and attenuate other portion(s). A method of analyzing constituents of a sample includes contemporaneously irradiating the sample with narrowband light and broadband light, the optical power of either modulated at a selected temporal frequency; dispersing wavelengths of resultant light across the optical detectors; and filtering respective signals from the optical detectors to provide spectrum data including signals corresponding to the selected temporal frequency.

主权项

1. A system for measuring an sample, the system comprising:
a) an illumination source adapted to provide electromagnetic radiation pulses, the providing having a selected temporal frequency; b) a microscope adapted to focus the provided electromagnetic radiation onto the sample, so that resultant electromagnetic radiation is produced by an interaction of the provided electromagnetic radiation with the sample; c) a plurality of optical sensors; d) a disperser adapted to disperse wavelengths of the resultant electromagnetic radiation onto the plurality of optical sensors; and e) a plurality of resonant amplifiers corresponding to respective ones of the optical detectors, each resonant amplifier operative to amplify signals having the selected temporal frequency.