The disclosure provides TNF-like ligand 1a (TL1a)-binding proteins comprising an antigen binding domain of an antibody which binds specifically to TL1a and inhibits interaction of TL1a and Death Receptor 3 (DR3) and which does not inhibit the interaction of TL1a and Decoy Receptor 3 (DcR3). The disclosure also provides uses of the TL1a-binding proteins.
申请公布号
EP2760889(A1)
申请公布日期
2014.08.06
申请号
EP20120835589
申请日期
2012.09.28
申请人
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD
发明人
POULTON, LYNN DOROTHY;CLARKE, ADAM;POW, ANDREW JAMES;TAMVAKIS, DEBRA;KOPSIDAS, GEORGE;DOYLE, ANTHONY GERARD;JENNINGS, PHILIP ANTHONY;POLLARD, MATTHEW