发明名称 |
LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BAEV ENV GLYCOPROTEINS |
摘要 |
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein; or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide. |
申请公布号 |
EP2761010(A1) |
申请公布日期 |
2014.08.06 |
申请号 |
EP20120766315 |
申请日期 |
2012.09.28 |
申请人 |
INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM);ECOLE NORMALE SUPERIEURE DE LYON |
发明人 |
GIRARD-GAGNEPAIN, ANAIS;VERHOEYEN, ELS;LAVILLETTE, DIMITRI;COSSET, FRANÇOIS-LOÏC |
分类号 |
C12N15/867;A61K48/00;C07K14/15 |
主分类号 |
C12N15/867 |
代理机构 |
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