Anti-malarial compounds

摘要

The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.

主权项

1. A compound of Formula I: wherein:
X is N(R9), O, S, S(═O), or S(═O)2;R9 is H or C1-C8alkyl;R1 and R2 are H;R3 and R4 are, independently, wherein each W, Y, and Z are, independently, C or N;each R5 is, independently, H or C1-C8alkoxy; andeach R6 is, independently, the free base or salt form of —(CH2)n—NH2, or —(CH2)n—NH—(CH2)n—NH2, or —(CH2)n—NH—C(═NH)NH2, where each n is, independently, 1 to 8; or a pharmaceutically acceptable salt thereof.