Methods and compositions for diagnosis and risk prediction in heart failure

摘要

The present invention relates in part to diagnosing the occurrence of heart failure, particularly in subjects who exhibit a normal body fluid level of a natriuretic peptide. The present invention further relates in part to assigning an outcome risk (e.g., worsening cardiac function or a mortality risk, a risk of rehospitalization) to a subject. The methods comprise performing one or more assays that detect one or more biomarkers selected from the group consisting of WAP4C, ESAM, LTBR, Mesothelin, and Syndecan-1 performed on a body fluid sample obtained from a subject, and assigning diagnosis or risk based, at least in part, on the result(s) obtained thereby.

主权项

1. A method of diagnosing heart failure in a subject, comprising:
performing one or more assays selected from the group consisting of an assay that detects WAP four-disulfide core domain protein 2, an assay that detects ESAM, an assay that detects LTBR, an assay that detects Mesothelin, an assay that detects Syndecan-1, an assay that detects TROY, and an assay that detects PIGR on a body fluid sample obtained from said subject, thereby providing one or more assay result(s); and assigning a diagnosis that the subject has or does not have heart failure based on the assay result(s) obtained.