Chemokine-immunoglobulin fusion polypeptides, compositions, method of making and use thereof

摘要

This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be used for treating chemokine receptor-mediated disorders and modulating inflammation, inflammatory cell motility, cancer cell motility, or cancer cell survival.

主权项

1. An isolated chemokine-immunoglobulin fusion polypeptide, comprising:
a CCL2 moiety and an immunoglobulin moiety comprising a constant region of a human immunoglobulin wherein when the chemokine-immunoglobulin fusion polypeptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:54.