| 主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,wherein:
A1 is C5-C10carbocyclyl or 5- to 10-membered heterocyclyl, and is substituted with —X1—R2, wherein said C5-C10-carbocyclyl and 5- to 10-membered heterocycly are optionally substituted with one or more RA; A2 is C5-C10carbocyclyl or 5- to 10-membered heterocyclyl, and is substituted with —X2—R8, wherein said C5-C10carbocyclyl and 5- to 10-membered heterocyclyl are optionally substituted with one or more RA; X1 and X2 are each independently selected from a bond, —LS—, —O—, —S—, or —N(RB)—; R7 and R8 are each independently selected from hydrogen, —LA, C5-C1-carbocyclyl, or 5- to 10-membered heterocyclyl, wherein at each occurrence said C5-C10carbocyclyl and 5- to 10-membered heterocyclyl are each independently optionally substituted with one or more RA; Z1 and Z2 are each independently selected from a bond, —C(RCRC′)—, —O—, —S—, or —N(RB)—; W1, W2, W3, and W4 are each independently selected from N or C(RD), wherein RD is independently selected at each occurrence from hydrogen or RA; R1 and R2 are each independently selected from hydrogen or RA; R3 and R4 are each independently selected from hydrogen or RA; or R3 and R4, taken together with the carbon atoms to which they are attached, form a C5-C10carbocyclic or 5- to 10-membered heterocyclic ring, wherein said C5-C10carbocyclic and 5- to 10-membered heterocyclic ring are optionally substituted with one or more RA; R5 and R6 are each independently selected from hydrogen or RA; or R5 and R6, taken together with the carbon atoms to which they are attached, form a C5-C10carbocyclic or 5- to 10-membered heterocyclic ring, wherein said C5-C10carbocyclic and 5- to 10-membered heterocyclic ring are optionally substituted with one or more RA; T is selected from a bond, —LS—, —LS—M—LS—, —LS—M—LS—M′—LS—, wherein M and M′ are each independently selected from a bond, —O—, —S—, —N(RB)—, —C(O)—, —S(O)2—, —S(O)—, —OS(O)—, —OS(O)2—, —S(O)2O—, —S(O)O—, —C(O)O—, —OC(O)—, —OC(O)O—, —C(O)N(RB)—, —N(RB)C(O)—, —N(RB)C(O)O—, —OC(O)N(RB)—, —N(RB)S(O)—, —N(RB)S(O)2, —S(O)N(RB), —S(O)2N(RB)—, —C(O)N(RB)C(O)—, —N(RB)C(O)N(RB′)—, —N(RB)SO2N(RB′)—, —N(RB)S(O)N(RB′)—, C5-C10carbocycle, or 5- to 10-membered heterocycle, and wherein R is optionally substituted with one or more RA; RA is independently selected at each occurrence from halogen, hydroxy, mercapto, amino, carboxy, nitro, phosphate, oxo, thioxo, formyl, cyano, —LA, or —LS—RB; RB and RB′ are each independently selected at each occurrence from hydrogen; or C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6carbocyclyl, C3-C6carbocyclylC1-C6alkyl, 3- to 6-membered heterocyclyl, or (3- or 6-membered heterocyclyl)C1-C6alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, phosphate, oxo, thioxo, formyl or cyano; RC and RC′ are each independently selected at each occurrence from hydrogen; halogen; hydroxy; mercapto; amino; carboxy; nitro; phosphate; oxo; thioxo; formyl; cyano; or C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, or C3-C6carbocyclyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, hydroxy, mercapto, amino, carboxy, nitro, phosphate, oxo, thioxo, formyl or cyano; LA is independently selected at each occurrence from C1-C6alkyl, C2-C6alkenyl, or C2-C6alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, phosphate, oxo, thioxo, formyl or cyano; LS, LS′ and LS″ are each independently selected at each occurrence from a bond; a C1-C6alkylene, C2-C6alkenylene, or C2-C6alkynylene, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —O—RS, —S—RS, —N(RSRS′), —OC(O)RS, —C(O)ORS, nitro, phosphate, oxo, thioxo, formyl or cyano; RE is independently selected at each occurrence from —O—RS, —S—RS, —C(O)RS, —OC(O)RS, —N(RS)C(O)N(RS′RS″), —N(RS)SO2RS′, —SO2N(RSR40), —N(RS)SO2N(RS′RS″), —N(RS)S(O)N(RS′RS″), —OS(O)—RS, —OS(O)2—RS, —S(O)2ORS, —S(O)ORS, —OC(O)ORS, —N(RS)C(O)ORS′, —OC(O)N(RSRS′), —N(RS)S(O)—RS′, —S(O)N(RSRS′), —C(O)N(RS)C(O)—RS′, C3-C6-carbocyclyl, or 3- to 6-membered heterocyclyl, and said C3-C6carbocyclyl and 3- to 6-membered heterocyclyl are each independently optionally substituted at each occurrence with one or more substituents selected from RS (except hydrogen), halogen, —O—RB, —S—RB, —N(RBRB′), —OC(O)RB, —C(O)ORB, nitro, phosphate, oxo, thioxo, formyl or cyano; and RS, RS′ and RS″ are each independently selected at each occurrence from hydrogen; or C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C3-C6carbocyclyl, C3-C6carbocyclylC1-C6alkyl, 3- to 6-membered heterocyclyl, or (3- to 6-membered heterocyclyl)C1-C6alkyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —O—RB, —S—RB, —N(RBRB′), —OC(O)RB, —C(O)ORB, nitro, phosphate, oxo, thioxo, formyl or cyano. |
