发明名称 |
METHODS OF DIAGNOSING CANCER USING EPIGENETIC BIOMARKERS |
摘要 |
The invention features methods of diagnosing cancer in a mammal (e.g., a human) by detecting a biomarker selected from a satellite II ribonucleic acid (RNA) molecule, a cancer-associated polycomb group (CAP) body, a cancer-associated satellite transcript (CAST) body, and UbH2A. Also featured is a method for identifying an agent for treating cancer in a mammal by contacting a cancer cell having a biomarker selected from a CAP body, a CAST body, and a satellite II RNA molecule with a test agent and determining whether the test agent reduces the level of the biomarker in the cancer cell. Other inventions featured are a method for determining whether a chemotherapeutic agent increases epigenetic imbalance of a cell and a method for detecting epigenetic imbalance by determining a copy number of a satellite II DNA locus at chromosome 1q12 in a cell. |
申请公布号 |
US2014213475(A1) |
申请公布日期 |
2014.07.31 |
申请号 |
US201214232552 |
申请日期 |
2012.07.16 |
申请人 |
Lawrence Jeanne B.;Hall Lisa;Byron Meg;Carone Dawn M. |
发明人 |
Lawrence Jeanne B.;Hall Lisa;Byron Meg;Carone Dawn M. |
分类号 |
C12Q1/68;G01N33/50;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method of diagnosing, or providing a prognostic indicator of, cancer in a mammal comprising detecting a biomarker selected from a satellite II ribonucleic acid (RNA) molecule, a cancer-associated polycomb group (CAP) body, and a cancer-associated satellite transcript (CAST) body in a sample from said mammal. |
地址 |
Mapleville RI US |