| 摘要 |
PROVIDED IS A METHOD FOR PRODUCING MESENCHYMAL STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS, THE METHOD INCLUDING: A) FORMING EMBRYONIC BODIES FROM HUMAN PLURIPOTENT STEM CELLS; B) ATTACHING THE EMBRYONIC BODIES TO A CULTURE DISH TO INDUCE NATURAL DIFFERENTIATION OF THE EMBRYONIC BODIES INTO MESENCHYMAL STEM CELLS; AND C) PERFORMING CONTINUOUS PROLIFERATIVE CULTURING OF THE MESENCHYMAL STEM CELLS WHILE STILL MAINTAINING THE IDENTITY OF THE MESENCHYMAL STEM CELLS. ALSO, PROVIDED IS A STANDARDIZED METHOD FOR INDUCING DIFFERENTIATION OF MESENCHYMAL STEM CELLS, WHICH CAN BE BROADLY APPLIED TO ALL HUMAN PLURIPOTENT STEM CELLS REGARDLESS OF A DIFFERENCE IN THE GENETIC BACKGROUND THEREOF. ULTIMATELY, THE PRESENT INVENTION CAN CONTINUOUSLY MASS-PRODUCES THE MESENCHYMAL STEM CELLS NECESSARY FOR REGENERATIVE MEDICINE AND CELL THERAPY BY USING HUMAN PLURIPOTENT STEM CELLS, THEREBY REALIZING PRACTICAL USES OF CELL THERAPY PRODUCTS, AND FURTHER THE PRESENT INVENTION IS EXPECTED TO HIGHLY CONTRIBUTE TO TREATMENTS OF INCURABLE DISEASES, SUCH AS CARDIOVASCULAR DISEASES AND NEUROLOGICAL DISORDERS. |
