SCREENING METHOD FOR THERAPEUTIC AGENT FOR CHONDROPATHY AND MODIFIED CHONDROCYTE FOR TREATMENT OF CHONDROPATHY

摘要

The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and/or a disease associated with impaired cartilage growth.

主权项

1. A screening method for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation, the method comprising using salt-inducible kinase 3 (SIK3).