| 摘要 |
The invention relates to 6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, in particular for therapeutic purposes, pharmaceutical agents and use thereof in therapy, in particular for the prevention and treatment of tumour diseases. |
| 主权项 |
1. Compounds of formula (I) in which either X stands for a bond and Y for a nitrogen atom or X stands for the —NH— group and Y stands for the —CH— group, and R1 and R2, independently of one another, stand for hydrogen or a C1-C6 alkyl group, and m is 0 or 1, and n is 0 or 1, and o is 0 or 1, and p is 0 or 1, wherein the sum of m, n, o and p is at least 2, if Rb1 and Rb2 form a bridge, and RS1 and RS1, independently of one another, stand for hydrogen or a C1-C6 alkyl group, or RS2 together with RS1 forms a keto group —C(O)—, or RS2 together with RS1 and the carbon atom to which RS1 and RS2 are bound, forms a saturated 3- to 8-membered carbocycle or heterocycle, which optionally
(i) can be substituted one or more times, identically or differently, with halogen, hydroxy, cyano, nitro and/or with a C1-C3 alkyl, halo-C1-C6 alkyl, C1-C6 alkoxy, halo-C1-C6 alkoxy, C1-C6-alkoxy-C1-C6 alkyl and/or C1-C6 alkylcarbonyl residue, and/or(ii) can contain a keto group —C(O)—, and Rb1 and Rb2 stand for hydrogen, or Rb1 and Rb2 form a bridge consisting of one of the groups
—O—, —C(O)—, —NR3—, —NR4—CHR5— or —CHR6—CHR7—wherein R3, R4, R5, R6 and/or R7, independently of one another, stand for hydrogen, a C1-C6 alkyl or C1-C6 alkoxy group or the group —C(O)—R8 with R8 standing for a C1-C6 alkyl or C1-C6 alkoxy group with the proviso, that either
Rb1 and Rb2 form a bridge,orRS2 together with RS1 and the carbon atom to which RS1 and RS2 are bound, forms a saturated 3- to 8-membered carbocycle or heterocycle, or that
Rb1 and Rb2 form a bridge,andRS2 together with RS1 and the carbon atom to which RS1 and RS2 are bound, forms a saturated 3- to 8-membered carbocycle or heterocycle, and the diastereomers, racemates and physiologically compatible salts thereof. |
