| 发明名称 |
SALTS AND CRYSTALLINE FORMS OF AN APOPTOSIS-INDUCING AGENT |
| 摘要 |
Salts and crystalline forms of 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}-sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide are suitable active pharmaceutical ingredients for pharmaceutical compositions useful in treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer. |
| 申请公布号 |
US2014213596(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
US201414228132 |
申请日期 |
2014.03.27 |
| 申请人 |
AbbVie Inc. |
发明人 |
Catron Nathaniel;Chen Shuang;Gong Yuchuan;Zhang Geoff G. |
| 分类号 |
C07D471/04 |
主分类号 |
C07D471/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound having the systematic name 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (Compound 1) in a salt or crystalline form. |
| 地址 |
North Chicago IL US |
