发明名称 LUMINESCENT PROBES FOR BIOLOGICAL LABELING AND IMAGING, AND PROCESS FOR PREPARING THE SAME
摘要 The present invention relates to organic compounds, usable as ligands in the preparation of lanthanide complexes or of certain water-soluble transition metals, a method for preparation thereof, and the use of said organic compounds as fluorescent probes.
申请公布号 US2014213777(A1) 申请公布日期 2014.07.31
申请号 US201214345705 申请日期 2012.09.20
申请人 CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 发明人 Ziessel Raymond;Starck Mathieu;Sutter Alexandra
分类号 C07D401/04 主分类号 C07D401/04
代理机构 代理人
主权项 1. A compound of formula (I) below:in which: n, o and p, independently of each other, are integers ranging from 0 to 4; A1 represents a function —COOR1 in which R1 is a hydrogen atom or an alkali metal cation; or a group A2; A2 represents a group —P(O)(OCH2CH3)(OR2) or —P(O)(OR2)2 in which R2 represents a hydrogen atom or an alkali metal cation; each of the groups Y1 and Y2 represents a hydrogen atom or alternatively Y1 and Y2 together form a diradical forming one or more aromatic or heteroaromatic rings with the two carbon atoms that bear them, said aromatic rings optionally bearing one or more substituents chosen from a hydrogen atom, an amino group and a thiol group, X represents a bond segment having a group selected from the groups consisting of an amide function —C(O)—NH— and a triple bond —C≡C—; Z is: NH2, a halogen, a phosphate,a group COOR3 in which R3 is H, an alkali metal cation, a quaternary ammonium group N(R4)4′ in which R4 is H or a linear alkyl chain preferably containing from 1 to 4 carbon atoms, a succinimide group —N—(CO—CH2—CH2—CO)— or a pentafluorophenyl group —C6F5;a biotin function (—CO—(CH2)4—C5H7N2OS), a polyheteroaromatic group or a crown ether,an organic or mineral silyl cluster;a macroscopic support.
地址 Paris FR