| 发明名称 |
MACROCYCLES |
| 摘要 |
Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described. |
| 申请公布号 |
US2014212381(A1) |
申请公布日期 |
2014.07.31 |
| 申请号 |
US201314059300 |
申请日期 |
2013.10.21 |
| 申请人 |
Scynexis, Inc. |
发明人 |
Li Keqiang;Peel Michael Robert |
| 分类号 |
C07K7/64;A61K38/13;C07C271/24;C07C321/28;A61K38/21;C07C229/48 |
主分类号 |
C07K7/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A cyclosporine A derivative in which the 3-Sarcosine position is substituted by a group —S—CH2C[CH2(CH2)n]NR2R3, wherein R2 is hydrogen or an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms, the chain is straight or branched; R3 is an alkyl chain having from one to four carbon atoms and, when the alkyl chain has 3 or 4 carbon atoms the chain is straight or branched; and n is 1 or 2. |
| 地址 |
Durham NC US |
