发明名称 |
Methods of generating hyper iNOS expressing cells and uses thereof |
摘要 |
A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell. |
申请公布号 |
US8790925(B2) |
申请公布日期 |
2014.07.29 |
申请号 |
US201313780503 |
申请日期 |
2013.02.28 |
申请人 |
Case Western Reserve University |
发明人 |
Lu Kurt Q.;Cooper Kevin D. |
分类号 |
C12N5/0786;A61K31/425;A61K31/21 |
主分类号 |
C12N5/0786 |
代理机构 |
Tarolli, Sundheim, Covell & Tummino LLP |
代理人 |
Tarolli, Sundheim, Covell & Tummino LLP |
主权项 |
1. A method of generating a hyper iNOS expressing cell comprising: administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell. |
地址 |
Cleveland OH US |