Method for producing preparations of substances poorly soluble in water

摘要

The invention relates to a process for producing formulations of sparingly water-soluble substances, said sparingly soluble substances being present in amorphous embedded form in a copolymer, and said copolymer being obtained by free-radically initiated polymerization of a mixture of
i) 30 to 80% by weight of N-vinyllactam,ii) 10 to 50% by weight of vinyl acetate, andiii) 10 to 50% by weight of a polyether,

with the proviso that the sum of components i), ii) and iii) equals 100% by weight, which comprises embedding the sparingly soluble substance into the copolymer at temperatures above the melting point of the sparingly soluble substances.

主权项

1. A process for producing a formulation of a sparingly water-soluble substance, the process comprising amorphously embedding a sparingly water-soluble substance in a graft copolymer, wherein the copolymer is obtained by free-radically initiated polymerization of a mixture of
i) 30 to 80% by weight of N-vinyllactam, ii) 10 to 50% by weight of vinyl acetate, and iii) 10 to 50% by weight of a polyether,with the proviso that the sum of components i), ii) and iii) equals 100% by weight, and wherein embedding the sparingly water-soluble substance into the copolymer occurs at a temperature above the melting point of the sparingly water-soluble substance.