Cyclooxygenase inhibitor and calcium channel antagonist compositions and methods for use in urological procedures

摘要

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

主权项

1. A locally deliverable composition for inhibiting pain/inflammation and spasm, comprising a combination of ketoprofen and nifedipine and at least one stabilizing agent in a liquid solvent irrigation carrier, each of the ketoprofen and the nifedipine included in a therapeutically effective amount such that the combination inhibits pain/inflammation and spasm at a site of local delivery, wherein the ketoprofen is included at a concentration of no more than 500,000 nanomolar, the nifedipine is included at a concentration of no more than 200,000 nanomolar, the at least one stabilizing agent comprises propyl gallate and the composition further comprises sodium metabisulfite.