Compositions and methods for inhibiting expression of the HAMP gene

摘要

The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the HAMP gene (HAMP gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the HAMP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HAMP gene expression and the expression of the HAMP gene using the pharmaceutical composition.

主权项

1. A double-stranded ribonucleic acid (dsRNA), wherein the dsRNA comprises an antisense strand and a sense strand, wherein each strand is less than 30 nucleotides in length, and wherein the target sequence of the dsRNA comprises the first nineteen nucleotides of SEQ ID NO:29 (GAACAUAGGUCUUGGAAUA).