| 摘要 |
The present invention relates to N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amine derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy, according to formula (I);
Wherein R1, R2, R3, R4, R5, R6 have the meaning defined in the claims.
;The invention particularly relates to positive allosteric modulators of nicotinic acetylcholine receptors, such positive allosteric modulator having the capability to increase the efficacy of nicotinic receptor agonists. |
| 主权项 |
1. A compound according to formula (I)or a stereochemically isomeric form thereof, wherein
R1 and R2 each independently represent hydrogen or C1-4alkyl; R3 is C1-6alkyl optionally substituted with one or more substituents independently selected from the group consisting of hydroxyl, cyano, C1-6alkyloxy, benzyloxy, RxRyN—C(═O)—, and RzO—C(═O)—; Rx and Ry each independently represent hydrogen, C1-4alkyl, cycloC3-6alkyl or (cycloC3-6alkyl)C1-4alkyl; Rz represents hydrogen or C1-3alkyl; R4, R5 and R6 each independently represent hydrogen, halo, C1-6alkyl, cyano, trifluoromethyl, trifluoromethoxy, or methoxy; or R4 and R5 when attached to 2 vicinal carbon atoms together form a bivalent radical of formula —O—CF2—O—; or a pharmaceutically acceptable addition salt thereof. |
