发明名称 |
IMPROVED ASSEMBLY OF BISPECIFIC ANTIBODIES. |
摘要 |
<p>Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.</p> |
申请公布号 |
MX2014004322(A) |
申请公布日期 |
2014.07.28 |
申请号 |
MX20140004322 |
申请日期 |
2012.10.11 |
申请人 |
GENENTECH, INC. |
发明人 |
SCHEER, JUSTIN;GIESE, GLEN;PERSSON, JOSEFINE;WILLIAMS, AMBROSE;LIM, AMY |
分类号 |
C07K16/46 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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